Big 12 opponents meet when the No. 22 Iowa State Cyclones (5-1) and the Colorado Buffaloes (2-4) play on Saturday, October 11, 2025 at Folsom Field.

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Iowa State vs. Colorado Matchup Info

Game date: Saturday, October 11, 2025
Game time: 3:30 p.m. ET
Location: Boulder, Colorado
Venue: Folsom Field
TV channel: ESPN
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Iowa State vs. Colorado Odds and Prediction

Spread favorite: Cyclones (-2.5)
Moneyline: Cyclones (-133), Buffaloes (+112)
Total: 52.5 points
Pick ATS: Iowa State (-2.5)
Pick OU: Under (52.5)
Prediction: Iowa State 28, Colorado 20

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Iowa State vs. Colorado Betting Records and Insights

Iowa State has put together a 3-2-1 record against the spread this season.
Colorado has covered three times in six games with a spread this year.
The Cyclones have covered the spread twice this season (2-1-1 ATS) when playing as at least 2.5-point favorites.
The Buffaloes have been an underdog by 2.5 points or more four times this season, and covered the spread in one of those games.
Iowa State and its opponent have combined to hit the over three out of six times this season.
This year, games featuring Colorado have hit the over twice.

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