The No. 22 Iowa State Cyclones (5-1) and the Colorado Buffaloes (2-4) play on Saturday, October 11, 2025 at Folsom Field in a clash of Big 12 opponents.
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Iowa State vs. Colorado Matchup Info
- Game date: Saturday, October 11, 2025
- Game time: 3:30 p.m. ET
- Location: Boulder, Colorado
- Venue: Folsom Field
- TV channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Iowa State vs. Colorado Odds and Prediction
- Spread favorite: Cyclones (-3)
- Moneyline: Cyclones (-152), Buffaloes (+128)
- Total: 52 points
- Pick ATS: Iowa State (-3)
- Pick OU: Under (52)
- Prediction: Iowa State 28, Colorado 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Iowa State vs. Colorado Betting Records and Insights
- Iowa State has put together a 3-2-1 ATS record so far this year.
- Colorado is 3-3-0 ATS this season.
- The Cyclones have covered the spread twice when favored by 3 points or more this season (in four opportunities).
- The Buffaloes have covered the spread once this season (1-3 ATS) when playing as at least 3-point underdogs.
- A total of three out of six Iowa State games this season have hit the over.
- Colorado games have hit the over twice this season.