Big 12 opponents match up when the Cincinnati Bearcats (3-1) and the No. 14 Iowa State Cyclones (5-0) square off on Saturday, October 4, 2025 at Nippert Stadium.
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Cincinnati vs. Iowa State Matchup Info
- Game date: Saturday, October 4, 2025
- Game time: 12 p.m. ET
- Location: Cincinnati, Ohio
- Venue: Nippert Stadium
- TV channel: ESPN2
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Cincinnati vs. Iowa State Odds and Prediction
- Spread favorite: Bearcats (-1)
- Moneyline: Bearcats (-115), Cyclones (-104)
- Total: 55.5 points
- Pick ATS: Iowa State (+1)
- Pick OU: Under (55.5)
- Prediction: Cincinnati 24, Iowa State 23
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Cincinnati vs. Iowa State Betting Records and Insights
- Cincinnati has won three games against the spread this season, while failing to cover once.
- Iowa State has covered three times in five games with a spread this year.
- The Bearcats have been favored by 1 point or more two times this season, and covered the spread in one of those contests.
- The Cyclones have covered the spread when playing as at least 1-point underdogs in their only opportunity this season.
- In Cincinnati's four games this season, the combined scoring has gone over the point total three times.
- This year, games featuring Iowa State have hit the over twice.