The No. 14 Iowa State Cyclones (4-0) host a Big 12 battle against the Arizona Wildcats (3-0) on Saturday, September 27, 2025 at Jack Trice Stadium.
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Iowa State vs. Arizona Matchup Info
- Game date: Saturday, September 27, 2025
- Game time: 7 p.m. ET
- Location: Ames, Iowa
- Venue: Jack Trice Stadium
- TV channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Iowa State vs. Arizona Odds and Prediction
- Spread favorite: Cyclones (-4.5)
- Moneyline: Cyclones (-185), Wildcats (+154)
- Total: 48.5 points
- Pick ATS: Arizona (+4.5)
- Pick OU: Under (48.5)
- Prediction: Arizona 21, Iowa State 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Iowa State vs. Arizona Betting Records and Insights
- Iowa State has a record of 2-1-1 against the spread this season.
- Arizona has covered twice in two games with a spread this year.
- The Cyclones have covered the spread once this season (1-1 ATS) when playing as at least 4.5-point favorites.
- Games featuring Iowa State have gone over the point total just once this season.
- So far this year, no Arizona game has hit the over.