The No. 16 Iowa State Cyclones (2-0) and the Iowa Hawkeyes (1-0) meet at Jack Trice Stadium on Saturday, September 6, 2025.
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Iowa State vs. Iowa Matchup Info
- Game date: Saturday, September 6, 2025
- Game time: 12 p.m. ET
- Location: Ames, Iowa
- Venue: Jack Trice Stadium
- TV channel: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Iowa State vs. Iowa Odds and Prediction
- Spread favorite: Cyclones (-3.5)
- Moneyline: Cyclones (-167), Hawkeyes (+141)
- Total: 41.5 points
- Pick ATS: Iowa State (-3.5)
- Pick OU: Over (41.5)
- Prediction: Iowa State 28, Iowa 23
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Iowa State vs. Iowa Betting Records and Insights
- Iowa State has won two games against the spread this season.
- Iowa has not won against the spread this year in one games with a spread.
- The Cyclones have won their only game this season when playing as at least 3.5-point favorites.
- Iowa State games have hit the over once this season.
- So far this season, no Iowa game has hit the over.